USCAP Lower Female Genital Tract Pathology: Practical Updates from the WHO and FIGO Classification and Reporting Systems 2025

Original release date: June 10, 2025

Course Description
This course is a comprehensive review of classification and reporting of lower female genital tract pathology (cervix, vagina, vulva), emphasizing updates from the new 5th edition World Health Organization classification system and new FIGO staging for cervical and vulvar cancers. Interactive microscopy cases will include biopsy specimens, resection specimens and cytopathological specimens. A practical approach to morphological assessment of neoplastic and non-neoplastic pathology will be complemented by strategies for selection and interpretation of key immunohistochemical stains and molecular diagnostic tests.

Learning Objectives
Upon completion of this educational activity, learners will be able to:

• Apply the current W.H.O. criteria for morphological, immunohistochemical and molecular diagnostic classification of cervical and vulvar epithelial tumors, mesenchymal tumors, and their non-neoplastic mimics.
• Assign the current FIGO staging criteria for cervical and vulvar carcinomas as well as the alternative Silva pattern of invasiveness for cervical adenocarcinoma.
• Classify non-neoplastic inflammatory and melanocytic disorders of the vulva.
• Diagnose exfoliative cytologic specimens of the cervix using current Bethesda system guidelines as well as pelvic fluid cytology specimens.